| ||||||
Depressed Adolescents Respond Best to Combination Treatment |
||||||||||||||||||||||||||||||
|
From EurekAlert! - Breaking News: A combination of psychotherapy and antidepressant medication appears to be the most effective treatment for adolescents with major depressive disorder---more than medication alone or psychotherapy alone, according to results from a major clinical trial funded by the National Institutes of Health's National Institute of Mental Health (NIMH). The long-term results of the Treatment for Adolescents with Depression Study (TADS) found that when adolescents received fluoxetine (Prozac) alone or in combination with cognitive behavioral therapy (CBT) over the course of 36 weeks, they recovered faster than those who were receiving CBT alone. However, taking fluoxetine alone appeared to pose some safety concerns for the teens. This suggests that while treatment with fluoxetine may speed recovery, adding CBT provides additional safeguards for those vulnerable to suicide, according to the researchers. "Depression in teens is a serious illness that can and should be treated aggressively," said NIMH Director Thomas R. Insel, M.D. "TADS provides compelling evidence for families and clinicians that the most effective way to treat depression in teens is with a two-pronged approach. Results at 36 weeks of treatment were consistent with those found at 12 weeks in the 439-person study, when NIMH reported that combination treatment produced the greatest improvement in teenagers with major depression. At 18 weeks (results not previously reported), combination treatment still outpaced the other treatments with an 85 percent response rate, compared to 69 percent for fluoxetine alone and 65 percent for CBT alone. The Treatment for Adolescents with Depression Study (TADS): Long-term Effectiveness and Safety Outcomes.
|
| |||||||||||||||||||||||||||||
